Thyrogen^® (thyrotropin alfa for injection)

Bibliographical Information:

Drug Name	Generic Name	Studied Indications or Disease	Approved U.S. Drug Label
Thyrogen®	thyrotropin alfa for injection	thyroid cancer	Prescribing Info

Protocol TSH91-0601

Meier, Christoph A. et al. Diagnostic Use of Recombinant Human Thyrotropin in Patients with Thyroid Carcinoma (Phase I/II Study). Journal of Clinical Endocrinology and Metabolism 78:188-196,1994.

Protocol TSH92-0601

Ladensen PW, Braverman LE, Mazzaferri EL, et al. Comparison of Administration of Recombinant Human Thyrotropin with Withdrawal of Thyroid Hormone for Radioactive Iodine Scanning in Patients with Thyroid Carcinoma. N Engl J Med 1997;337:888-96.

Protocol TSH94-0301

No associated publications.

Protocol TSH95-0101

Haugen BR, Pacini F, Reiners C, et al. A Comparison of Recombinant Human Thyrotropin and Thyroid Hormone Withdrawal for the Detection of Thyroid Remnant or Cancer. J Clin Endocrinol Metab 1999;84:3877-85.

Protocol THYR-007-00

Richard J. Robbins, Albert Driedger, James Magner. The U.S. and Canadian Thyrogen compassionate Use Program (TCUP) Investigator Group. November 2006, 16(11): 1121-1130. doi:10.1089/thy.2006.16.1121

Protocol THYR-008-00

Pacini F, Ladenson PW, Schlumberger M, et al. Radioiodine Ablation of Thyroid Remnants after Preparation with Recombinant Human Thyrotropin in Differentiated Thyroid Carcinoma: Results of an International, Randomized, Controlled Study. J Clin Endocrinol Metab. 2006;91:926-932.

Ladenson P, Pacini F, Schlumberger M, Driedger A, Kloos R, Sherman S, et al. Thyroid remnant ablation: a randomized comparison of thyrotropin alfa and thyroid hormone withdrawal [abstract]. Presented at the ENDO 2004: Endocrine Society 86th Annual Meeting; June 16-19, 2004; New Orleans, LA. p. S35-1.

Protocol THYR-1605

R. Elisei, M. Schlumberger, A. Driedger, C. Reiners, R. T. Kloos, S. I. Sherman, B. Haugen, C. Corone, E. Molinaro, L. Grasso, S. Leboulleux, I. Rachinsky, M. Luster, M. Lassmann, N. L. Busaidy, R. L. Wahl, F. Pacini, S. Y. Cho, J. Magner, A. Pinchera, and P. W. Ladenson. .Follow-Up of Low-Risk Differentiated Thyroid Cancer Patients Who Underwent Radioiodine Ablation of Postsurgical Thyroid Remnants after Either Recombinant Human Thyrotropin or Thyroid Hormone Withdrawal J. Clin. Endocrinol. Metab., Nov 2009; 94: 4171 - 4179.